65212-37-5Relevant articles and documents
Semisynthetic aminoglycoside antibacterials. 6. Synthesis of sisomicin, antibiotic G-52, and novel 6'-substituted analogues of sisomicin from aminoglycoside 66-40C
Davies,Mallams,Counelis,Loebenberg,Moss Jr.,Waitz
, p. 189 - 193 (2007/10/05)
The discovery of aminoglycoside 66-40C, a novel dimeric, unsaturated imine produced by Micromonospora inyoensis, afforded a versatile intermediate for the synthesis of a variety of sisomicin analogues modified at the 6' position. The conversion of 66-40C into sisomicin, antibiotic G-52, and a series of novel 6'-substituted analogues of sisomicin is described, and the biological activity of the products is discussed.