A Novel Route to Chiral trans-6-Alkyl-2-hydroxymethyl-1,2,5,6-tetrahydropyridines by Allylation of Chiral Imines and Ring-Closing Metathesis - Total Synthesis of (-)-3-epi-Deoxoprosopinine
A novel route to enantiomerically pure trans-6-alkyl-2-hydroxymethyl-1,2,5,6-tetrahydropyridines is reported in five steps from Garner's aldehyde with overall yields higher than 35%. This strategy is based on the allylation of chiral imino alcohols formed
Felpin, Francois-Xavier,Boubekeur, Kamal,Lebreton, Jacques
p. 4518 - 4527
(2007/10/03)
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