Development of N6-(Heteroarylcarbonyl) adenines as BRD4 inhibitors
N6-(Heteroarylcarbonyl)adenines were synthesized as candidate BRD4 inhibitors, and their structure-activity relationships were investigated. Among the synthesized compounds, N6-[(3-methoxythiophen-2-yl)carbonyl]adenine (15) showed th
COMPOSITIONS AND METHODS USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE
The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable salts thereof, for the treatment and/or prevention of neurodegenerative disease and/or mitchonodrial disease including Parkinson's disease and Leigh's disease.
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Page/Page column 129
(2015/09/22)
Structure determination of N6-, 9- and 7-acyladenines by 1H- and 13C-NMR spectroscopy of solids and in solution
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Ried,Woithe,Muller
p. 1597 - 1607
(2007/10/02)
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