65428-04-8Relevant articles and documents
COMPOSITIONS AND METHODS OF TREATING UPS-ASSOCIATED DISEASES
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, (2022/01/24)
The present invention relates to methods for treating a disease characterized by aberrations in the ubiquitin/proteasome system (UPS).
NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
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Page/Page column 26; 31, (2018/07/29)
Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
Synthesis, anticancer, structural, and computational docking studies of 3-benzylchroman-4-one derivatives
Simon, Lalitha,Abdul Salam, Abdul Ajees,Madan Kumar,Shilpa,Srinivasan,Byrappa
, p. 5284 - 5290 (2017/10/30)
A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell
Microbial Transformations of 7-Methoxyflavanone
Kostrzewa-Suslow, Edyta,Janeczko, Tomasz
, p. 14810 - 14820 (2013/02/26)
Microbial transformations of racemic 7-methoxyflavanone using strains of the genus Aspergillus (A. niger KB, A. ochraceus 456) and the strain Penicillium chermesinum 113 were described. The strain A. niger KB catalysed carbonyl group reduction, leading to (±)-2,4-cis-7-methoxyflavan-4-ol. Biotransformation with the help of A. ochraceus 456 gave two products: (+)-2,4-trans-7-methoxyflavan-4-ol and 4'-hydroxy-7-methoxyflavone. Transformation by means of P. chermesinum 113 resulted in a dihydrochalcone product, 4,2'-dihydroxy-4'-methoxydihydrochalcone. DPPH scavenging activity test proved that all the biotransformations products have higher antioxidant activity that the substrate.