A metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes
An intermolecular reductive C-C coupling of electrophilic alkyl radicals and alkenes has been developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of triethyl phosphite and radical initiator. A wide range of alkenes, including styrenes, and aliphatic olefins were well tolerated in this transformation. Mechanistic studies indicated that a phosphite promoted radical desulfurization of thiols to access electrophilic alkyl radicals and a radical chain propagation process may be involved in this transformation.
Qin, Qixue,Wang, Weijing,Zhang, Cheng,Song, Song,Jiao, Ning
supporting information
p. 10583 - 10586
(2019/09/06)
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