A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite promising
Cui, Huarui,Divakaran, Anand,Hoell, Zachariah J.,Ellingson, Mikael O.,Scholtz, Cole R.,Zahid, Huda,Johnson, Jorden A.,Griffith, Elizabeth C.,Gee, Clifford T.,Lee, Amani L.,Khanal, Shalil,Shi, Ke,Aihara, Hideki,Shah, Vijay H.,Lee, Richard E.,Harki, Daniel A.,Pomerantz, William C. K.
p. 2342 - 2360
(2022/01/27)
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