- CHLOROBENZENE SUBSTITUTED AZAARYL COMPOUNDS
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The invention provides a series of chlorobenzene substituted azaaryl compounds having activity in inhibiting cancer cell growth and low toxicity to normal cells. Particularly, the compounds of the invention have stronger inhibition effect on bladder cance
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Paragraph 0077
(2017/02/09)
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- INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE
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Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
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Page/Page column 257; 258
(2017/11/10)
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- NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS
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Derivatives of N,N-diethyl-N'- phenyl-piperazine, a silent agonist of the mammalian α7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. Further provided are pharmaceutical compositions that allow the administration of the silent agonists of the disclosure to a subject animal or human in need of treatment for a pathological condition arising from such as inflammation. The novel silent agonists also may be co-administered to a patient simultaneously or consecutively with a type II positive allosteric modulator to modulate the activity of the receptor.
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Page/Page column 35; 36; 39
(2017/05/02)
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- Imidazothiazolone deriv.
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PROBLEM TO BE SOLVED: To provide a compound having excellent Pim kinase inhibitory action and useful as anticancer agent, and a medicament comprising the compound.SOLUTION: This invention relates to a thiazolone derivative compound represented by the following compound, and a medicament comprising the compound.
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Paragraph 0234; 0235; 0236
(2017/01/05)
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- AROMATIC COMPOUND
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An aromatic compound represented by the following formula or a pharmaceutically acceptable salt thereof: , wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., G1, G2, G3, G4 and G5 are CH or N, X is -NH-, -O-, -CH2-, etc., Y is - CH2-,-CO-,-SO2- etc., Z is a single bond, -CO-, -SO2-, -NH-, -O-, -S-, -CONH-,-SO2NH-, etc., R2 is hydrogen, alkyl, alkoxy, halogen, etc., and R3 is carbocyclic group, heterocyclic group, alkyl, etc., is useful as a controlling agent of the function of CCR4 useful for the treatment or therapy for bronchial asthma, atopic dermatitis, etc.
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Page/Page column 88
(2008/12/07)
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- SPIRO COMPOUNDS, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THE COMPOUNDS
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A spiro compound represented by the following formula (I) wherein R1 and R2 are the same or different and each is a hydrogen atom, a chlorine atom and the like, n is 1, 2 or 3, a bond containing a broken line is a single bond or a do
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Page/Page column 25
(2010/02/13)
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- COMPOUNDS
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The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.
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- 2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS
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This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.
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