- Synthesis and Biological Activity of some Fused &β-Lactam Peptidoglycan Analogues
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The derivatives (12), (14), (15), (19), and (22), in which a mono- or di-peptide unit is linked to 6-aminopenicillanic acid, have been prepared according to normal synthetic peptide procedures.The structures of the side chains were chosen by analogy with the D-isoglutamyl-L-lysyl sequence present in the cell-wall peptidoglycan of Staphylococcus species.The antibacterial activities of the derivatives were measured and the results are discussed.
- Bentley, Peter H.,Stachulski, Andrew V.
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p. 1187 - 1192
(2007/10/02)
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