- PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES
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The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to
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Page/Page column 16
(2010/11/28)
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- Cysteine derivatives as inhibitors for carboxypeptidase A: Synthesis and structure-activity relationships
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A series of cysteine (Cys) derivatives having an alkyl or arylalkyl moiety on the α-amino group of the amino acid have been synthesized as a novel type of inhibitor for carboxypeptidase A. These compounds are readily prepared starting with Cys in an optic
- Park, Jung Dae,Kim, Dong H.
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p. 911 - 918
(2007/10/03)
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- Novel methods for the synthesis of 3-arylmethyl-4-thiazolidine carboxylic acid-2-thiones and their methyl esters
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Reductive amination, using benzaldehyde derivatives and sodium borohydride, on L-cystine yields N,N'-di (arylmethyl) cystines 7a-c which can be converted into N, N'-di(arylmethyl) cystine dimethyl esters 8a-c by esterification. The reductive reaction by zinc, hydrochloric acid and methanol on the derivatives 7 and 8 yields the thiols 4a-c and 5a-c, respectively which on reaction with CS2 or EtOCS2K are further converted into 3-arylmethyl-4-thiazolidine carboxylic acid-2-thiones 1a-c and their methyl esters 2a-c. Compounds 2a-c are also produced by esterification of 1a-c. Fewer reaction steps and higher yields are the advantages of these methods.
- Ghiaci,Tabrizi
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