Synthesis and contractile activity of substituted 1,2,3,4- tetrahydroisoquinolines
A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines was synthesized in high yields from different ketoamides. We have developed a convenient method for the synthesis of disubstituted derivatives by interaction of
Development of the Pictet-Spengler reaction catalyzed by AuCl 3/AgOTf
Mild and efficient AuCl3/AgOTf-catalyzed Pictet-Spengler reactions were developed to afford in good yields a variety of tetrahydroisoquinoline and tetrahydro-β-carboline ring systems, which constitute important motifs in biologically active nat
Youn, So Won
p. 2521 - 2523
(2007/10/03)
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist
N-Acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential noncompetitive AMPA receptor antagonists on the basis of molecular modeling studies. Sound-induced seizure testing showed that this class o
Gitto, Rosaria,Barreca, Maria Letizia,De Luca, Laura,De Sarro, Giovambattista,Ferreri, Guido,Quartarone, Silvana,Russo, Emilio,Constanti, Andrew,Chimirri, Alba
p. 197 - 200
(2007/10/03)
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