Screening of the Merck compound collection identified 6 as an unusually simple, low molecular weight hit with moderate affinity for GABAA receptors. The structural novelty of 6, compared to our advanced series of GABAA α5 inverse ago
Van Niel, Monique B.,Wilson, Kevin,Adkins, Charles H.,Atack, John R.,Castro, José L.,Clarke, Dawn E.,Fletcher, Stephen,Gerhard, Ute,Mackey, Mark M.,Malpas, Sallie,Maubach, Karen,Newman, Robert,O'Connor, Desmond,Pillai, Gopalan V.,Simpson, Peter B.,Thomas, Steven R.,MacLeod, Angus M.
p. 6004 - 6011
(2007/10/03)
PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevent
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Page 63
(2008/06/13)
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