Potent and selective CC chemokine receptor 1 antagonists labeled with carbon-13, carbon-14, and tritium
1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide (1) and its analogs (2) and (3) are potent CCR1 antagonists intended for the treatment of rheumatoid arthritis. The detailed syntheses of these 3
Latli, Bachir,Hrapchak, Matt,Cheveliakov, Maxim,Reeves, Jonathan T.,Marsini, Maurice,Busacca, Carl A.,Senanayake, Chris H.
AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS
Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
-
Page/Page column 169
(2010/04/27)
More Articles about upstream products of 66154-69-6