- Nicotinamide Riboside Derivatives Conjugated with Fatty Alcohol
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The present invention relates to nicotinamide riboside derivatives conjugated with fatty alcohol, and a composition for wrinkle reduction or antiaging comprising the same. The nicotinamide riboside derivatives conjugated with fatty alcohol according to the present invention have increased stability and body absorption, and hydrolyze in the body to supply NAD precursors, thereby being effectively used for cosmetic compositions, pharmaceutical compositions, and health functional foods for wrinkle reduction or antiaging.(AA) Comparative example compound (NR)(B2,B3) Time(BB) Compound of example 8(CC) Compound of example 7COPYRIGHT KIPO 2020
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Paragraph 0077-0079
(2020/04/17)
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- Sunfish amphiphiles: Conceptually new carriers for DNA delivery
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A conceptually new class of cationic amphiphiles, Sunfish amphiphiles, designed for the delivery of genes into cells is introduced. Sunfish amphiphiles have two hydrophobic tails, connected at the 4- and the N-position to the cationic pyridinium headgroup. Two extreme morphologies visualised by backfolding and combining of both tails at one site (matching situation) or unfolding of the tails at distinct interaction sites at biological membranes will lead to considerable differences in morphological behaviour. The underlying rationale allows controlled release by using this morphological alteration of the Sunfish/helper-lipid/DNA complex (lipoplex). The often-excellent transfection efficiencies are probably related to these morphological changes. In addition, the Sunfish amphiphiles possess low toxicities, resulting in high cell survival after internalisation. The underlying rationale, design, synthesis and in vitro transfection potential are discussed in detail. Moreover, some physico-chemical characteristics of the Sunfish amphiphiles have been studied. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
- Hulst, Ron,Muizebelt, Inouk,Oosting, Peter,Van Der Pol, Cornelia,Wagenaar, Anno,Smisterova, Jarmila,Bulten, Erna,Driessen, Cecile,Hoekstra, Dick,Engberts, Jan B. F. N.
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p. 835 - 849
(2007/10/03)
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- CONVENIENT SYNTHESIS OF ESTERS OF 2-PYRROLECARBOXYLIC ACID AND OF PYRIDINECARBOXYLIC ACIDS BY SOLID-LIQUID PHASE TRANSFER CATALYSIS WITHOUT ADDED SOLVENT
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By reaction of aromatic K-carboxylates having nucleophilic N-atom in solid-liquid phase transfer catalysis (PTC) conditions without added solvent (catalyst : tetraalkylammonium halide) with alkylating reagents, the corresponding esters are prepared.By a judicious choice of experimental conditions, the amounts of N-alkylated products can be lowered.From 2-pyrrolecarboxylic acid, the three isomers of pyridinecarboxylic acid and o-aminobenzoic acid, corresponding esters of ethyl, benzyl, n-octyl and n-cetyl, generally are obtained with good yields.
- Barry, Jean,Bram, Georges,Petit, Alain
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p. 875 - 880
(2007/10/02)
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