Reaction of aziridinium ions with organometallic reagents: Optimization of the key step of ecopipam synthesis
Formation, stability and reactivity of aziridinium ions 3 towards organometallic reagents was explored and optimized for the efficient preparation of key drug intermediate 5c.
Andrews, David R,Dahanukar, Vilas H,Eckert, Jeffrey M,Gala, Dinesh,Lucas, Brian S,Schumacher, Doris P,Zavialov, Ilia A