- N2,N2′-disubstituted oxalic acid bishydrazides: Novel ligands for copper-catalyzed Ci£N coupling reactions in water
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A series of N2,N2′-disubstituted oxalic acid bishydrazides were synthesized. Some, for example, N2,N 2′-di-1-(4-methoxyphenyl)-ethanyloxylic-(bishydrazide), are novel and effective ligands for copper-catalyzed Ullmann-type Ci£N coupling reaction in water. A variety of amines could be effectively N-arylated with aryl halides under both microwave irradiation and conventional heating (even at 30 °C) with good to excellent yields.
- Meng, Fei,Wang, Chenxia,Xie, Jianwei,Zhu, Xinhai,Wan, Yiqian
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experimental part
p. 341 - 347
(2012/05/04)
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