66333-88-8

Basic information

• Product Name: OXAZOLE, 5-METHYL-
• Synonyms: OXAZOLE, 5-METHYL-
• CAS NO: 66333-88-8
• Molecular Formula: C₄H₅NO
• Molecular Weight: 83.0886
• Mol File: 66333-88-8.mol

Chemical Properties

• Boiling Point: 88 °C at 760 mmHg
• Flash Point: 20.5 °C
• Appearance: /
• Density: 1.016 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.70±0.10(Predicted)
• CAS DataBase Reference: OXAZOLE, 5-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: OXAZOLE, 5-METHYL-(66333-88-8)
• EPA Substance Registry System: OXAZOLE, 5-METHYL-(66333-88-8)

Safety Data

• Hazardous Substances Data: 66333-88-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Oxazole, 5-methylis used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of biologically active molecules. Its unique structure allows for the creation of compounds with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, Oxazole, 5-methylserves as a building block in the synthesis of agrochemicals, helping to develop products that can enhance crop protection and management.
Used in Organic Compounds Synthesis:
Oxazole, 5-methylis utilized in the synthesis of other organic compounds, demonstrating its versatility as a chemical intermediate that can be incorporated into a wide array of molecules for various applications.
Used as a Solvent in Chemical Reactions:
Due to its properties as a colorless liquid with a fruity odor, Oxazole, 5-methylis also used as a solvent in certain chemical reactions, facilitating processes that require specific conditions or environments.
Overall, the applications of Oxazole, 5-methylspan across different industries, highlighting its importance in the synthesis of a broad spectrum of products, from pharmaceuticals to agrochemicals, and its utility in chemical reactions as a solvent.

Upstream product

• 15625-88-4 1-acetyl-1H-[1,2,4]triazole 
• 74616-91-4 5-Methyl-4-oxazolcarbonsaeure-Natriumsalz 
• 103879-58-9 5-methyloxazole-4-carboxylic acid 

Downstream Products

• 129053-67-4 2-bromo-5-methyl-oxazole 

Relevant articles and documents

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks

An approach to synthesis of 2-, 4-, and 5-bromooxazoles is described. The method was optimized, and its scope was extended to all three isomeric parents, as well as various alkyl- and aryl-substituted bromooxazoles. It was found that direct regiocontrolled lithiation followed by reaction with electrophilic bromine source was common for all substrates and led exclusively to the target substituted 2-, 4- and 5-bromooxazoles on multigram scale. The utility of the multipurpose building blocks obtained in this work was demonstrated in the Suzuki–Miyaura cross-coupling reaction under parallel synthesis conditions.

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

PYROLYSE-ECLAIR SOUS VIDE DE 1,2,4-TRIAZOLIDES = UNE ETUDE PAR SPECTROMETRIE DE MASSE EN TANDEM

A real-time analysis of the flash-vacuum pyrolysis products of some 1,2,4-triazolides has been performed by tandem mass spectrometry.Beside decay products, ketenes and the parent 1,2,4-triazole, 1-acyltriazoles give rise to 5-alkyloxazoles and nitrogen.This ring transformation reaction implies a sigmatropic shift of the acyl group from nitrogen to carbon, loss of nitrogen and cyclisation of the biradical intermediate. 5-aryloxazoles are similarly obtained from 1-aroyltriazoles.

CONVERSION OF TRIAZOLIDES INTO OXAZOLES BY FLASH-VACUUM PYROLYSIS.

Flash-vacuum pyrolysis of azolides of 1,2,4-triazole affords 5-monosubstituted oxazoles.

Note on the Preparation of 5-Methyloxazole

The title compound 4 was synthesized starting from methyl isocyanoacetate (1).