- COMPOUND LIBRARY PREPARATION PROCESS BASED ON EXCHANGE REACTION BETWEEN DIFERENTLY SUBSTITUTED DIOXABOROLANES OR DIOXABORINANES
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The present invention relates to the preparation of a compound library comprising the following steps: ? i. Having available at least two different compounds each comprising at least a dioxaborolane or dioxaborinane ring. In said compounds: ? -the boron of the dioxaborolane or dioxaborinane ring is directly linked to a carbon atom of a hydrocarbon radical; ? -at least one carbon atom of the dioxaborolane or dioxaborinane ring is monosubstituted, the other carbon atoms are non- substituted or monosubstituted; ? -in at least two compounds, the hydrocarbon radicals linked to the boron are different; ? - in at least two compounds, either the dioxaborolane or dioxaborinane ring carbon atoms are differently substituted and/ or the size varies. ? ii. Reacting the compounds of step (i.) and forming, by a boronic ester metathesis reaction, the library comprising at least four different compounds. The present invention also relates to a compound library. Illustrative for the present invention is the following figure:
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Page/Page column 28-29
(2017/03/21)
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- Insight into Copper Catalysis: In Situ Formed Nano Cu2O in Suzuki-Miyaura Cross-Coupling of Aryl/Indolyl Boronates
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A ligand-free copper catalyzed Suzuki-Miyaura coupling of 3,5-diiodopyridine with aryl and indole boronates has been explored in good to excellent yields. In situ generation of nano-Cu2O from CuCl2 under the reaction conditions has been discovered for the first time. The generality of the reaction was further demonstrated by the arylation of 5-iodopyrimidine, iodopyridines, iodobenzenes, and diiodobenzenes and resulted in good to moderate yields. Moreover, bisindole alkaloid Scalaridine A has been successfully synthesized in 60% overall yield.
- Ranjani, Ganapathy,Nagarajan, Rajagopal
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supporting information
p. 3974 - 3977
(2017/08/14)
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- Diol lipids - Communication 27. Identification of C2-C4-diols in the form of cyclic esters of phenylboric acid by the method of combined gas chromatography and mass spectrometry
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1. A new method was proposed for the analysis of small quantities of C2-C4-diols, formed in the cleavage of lipids, based on combined gas-chromatography and mass spectrography of their phenylborate esters. 2. Phenylborate esters of d
- Batrakov,Panosyan,Ushakov,Rozynov,Bergel'son
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p. 1662 - 1668
(2007/10/10)
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