664322-58-1

Basic information

• Product Name: 5-(CHLOROMETHYL)-3-(2-METHYLPHENYL)-1,3-OXAZOLIDIN-2-ONE
• Synonyms: 5-(CHLOROMETHYL)-3-(2-METHYLPHENYL)-1,3-OXAZOLIDIN-2-ONE
• CAS NO: 664322-58-1
• Molecular Formula: C₁₁H₁₂ClNO₂
• Molecular Weight: 225.67
• Mol File: 664322-58-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(CHLOROMETHYL)-3-(2-METHYLPHENYL)-1,3-OXAZOLIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(CHLOROMETHYL)-3-(2-METHYLPHENYL)-1,3-OXAZOLIDIN-2-ONE(664322-58-1)
• EPA Substance Registry System: 5-(CHLOROMETHYL)-3-(2-METHYLPHENYL)-1,3-OXAZOLIDIN-2-ONE(664322-58-1)

Safety Data

• Hazardous Substances Data: 664322-58-1(Hazardous Substances Data)

Upstream product

• 614-68-6 2-tolyl isocyanate 
• 106-89-8 epichlorohydrin 

Relevant articles and documents

Tetraarylphosphonium Salt-Catalyzed Synthesis of Oxazolidinones from Isocyanates and Epoxides

Preparation of a range of oxazolidinones, including enantioenriched N-aryl-substituted oxazolidinones, in which tetraarylphosphonium salts (TAPS) catalyze the [3 + 2] coupling reaction of isocyanates and epoxides effectively, is described. The key finding is a Br?nsted acid/halide ion bifunctional catalyst that can accelerate epoxide ring opening with high regioselectivity. Mechanistic studies disclosed that the ylide generated from TAPS, along with the formation of halohydrins, plays a crucial role in the reaction with isocyanates.

A facile and efficient synthesis of 3-aryloxazolidin-2-ones from isocyanates and epoxides promoted by MgI2 etherate

We described a mild and efficient procedure for the synthesis of 3-aryloxazolidin-2-ones via the cycloaddition of isocyanates with epoxides in the presence of MgI2 etherate (MgI2(OEt2)n) in good yields. Copyright