66492-66-8Relevant articles and documents
2'Hydroxy tetrazole-5-carboxanilides and anti-allergic use thereof
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, (2008/06/13)
New tetrazole derivatives of the general formula: STR1 [wherein R1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula: (wherein R2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 5 carbon atoms, an aryl, aralkyl or trifluoromethyl group, or a cycloalkyl group containing from 3 to 8 carbon atoms, and R3 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms optionally substituted by a phenyl group, or represents an aryl group optionally substituted by one or more substituents selected from halogen atoms and straight- or branched-chain alkyl and alkoxy groups containing from 1 to 6 carbon atoms and hydroxy, trifluoromethyl and nitro groups), and m represents zero or an integer 1, 2 or 3, the substituents R1 being the same or different when m represents 2 or 3] possess pharmacological properties, in particular properties of value in the treatment of allergic conditions.
N-Benzyl and N-substituted benzyl tetrazole-5-carboxylic acids and the preparation thereof
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, (2008/06/13)
N-Protected-tetrazole-5-carboxylic acid derivatives of the formula: STR1 in which R is --OM, halo or lower alkoxy wherein M is hydrogen, an alkali metal or an alkaline earth metal; and R1 is phenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl or 2,4,6
5-Tetrazolecarboxamides and Their Salts: New Orally Active AntiAllergy Agents
Klaubert, Dieter H.,Sellstedt, John H.,Guinosso, Charles J.,Bell, Stanley C.,Capetola, Robert J.
, p. 748 - 752 (2007/10/02)
A new series of orally active antiallergy agents, tetrazole-5-carboxamides, has been prepared by acylation of substituted anilines or aminopyridines with 1-benzyl- or 4-(methoxybenzyl)-5-tetrazolecarbonyl chloride and subsequent removal of the benzyl subs
