- Method for preparing 1-(3-methoxypyridine-2-yl)-2-acetone
-
The invention discloses a novel preparation method of a common novel broad-spectrum anticoccidial drug halofuginone intermediate, and relates to a specific preparation method of a compound 1-(3-methoxypyridine-2-yl)-2-acetone. The method sequentially comprises the following steps of: by taking 2-methyl-3-methoxy pyridine as a raw material, performing exchange to obtain a corresponding Grignard reagent; making the Grignard reagent react with acetic anhydride to form a seven-membered ring intermediate product; and finally hydrolyzing the seven-membered ring intermediate product to obtain the product. The invention provides a brand-new synthetic route; the used raw materials are mature in process, sufficient in market supply and wide in source; the reaction conditions of each step are mild, and the process is simple. The method can be applied to large-scale production.
- -
-
Paragraph 0003
(2021/01/30)
-
- Pyridine compounds and their pharmaceutical use
-
A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthasey)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-ependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.
- -
-
-