- Isolation and characterization of two major degradation products of dyclonine hydrochloride
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Dyclonine hydrochloride, a local anesthetic, is known to degrade in aqueous media. In this paper, the isolation and characterization of two major degradation products, formed by heating of an aqueous solution of dyclonine hydrochloride for 2 weeks at 50 °C, are presented. The proton and carbon-13 nuclear magnetic resonance, infrared, and mass spectral data reported conclusively show the two products to be 1-(4-butoxyphenyl)-2-propen-1-one and 1-(4-butoxyphenyl)-3-hydroxy-1-propanone. The proton and carbon-13 nuclear magnetic resonance spectral data of the free dyclonine base are also included.
- Liang,Yang,Khadim,Banker,Kumar
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- Synthesis and mesogenic properties of 3,6-disubstituted cyclohex-2-en-l-ones
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A series of 3,6-substituted cydohex-2-en-l-ones have been prepared by an efficient convergent Robinson-type annulation route. The cyclohex-2-en-l-one ring is the basis of a novel mesogenic core and when substituted at the 6-position provides a chiral cent
- Brettle, Roger,Dunmur, David A.,Farrand, Louise D.,Marson, Charles M.
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p. 747 - 751
(2007/10/03)
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- 3-Arylcyclohex-2-en-1-ones and 2,6-Diarylcyclohex-2-en-1-ones. New Liquid Crystalline Compounds
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The cyclohex-2-en-1-one unit flanked by one or more aryl rings is shown to provide a new system which can exhibit liquid crystal properties; these new mesogens contain a chiral centre which is both adjacent to a lateral dipolar carbonyl group and its also located in the central core.
- Brettle, Roger,Dunmur, David A.,Farrand, Louise D.,Hindley, Nigel J.,Marson, Charles M.
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p. 1663 - 1666
(2007/10/02)
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