66548-21-8

Basic information

• Product Name: tert-butyl-methoxy-dimethylsilane
• Synonyms: tert-butyl-methoxy-dimethylsilane;t-Butyl Dimethyl Methoxysilane;Silane, (1,1-dimethylethyl)methoxydimethyl-
• CAS NO: 66548-21-8
• Molecular Formula: C₇H₁₈OSi
• Molecular Weight: 146.30272
• EINECS: -0
• Mol File: 66548-21-8.mol

Chemical Properties

• Boiling Point: 117-118 °C
• Appearance: /
• Density: 0.785±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: tert-butyl-methoxy-dimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl-methoxy-dimethylsilane(66548-21-8)
• EPA Substance Registry System: tert-butyl-methoxy-dimethylsilane(66548-21-8)

Safety Data

• Hazardous Substances Data: 66548-21-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Tert-butyl-methoxy-dimethylsilane is used as a protecting group for alcohol functional groups in organic synthesis, allowing chemists to temporarily mask these groups during reactions to prevent unwanted side reactions.
Used in Pharmaceutical Production:
In the pharmaceutical industry, tert-butyl-methoxy-dimethylsilane is utilized as a reagent in the synthesis of various drugs, contributing to the development of new medicinal compounds.
Used in Agrochemical Production:
Similarly, in agrochemical manufacturing, this compound is employed to synthesize a range of products, including pesticides and herbicides, enhancing crop protection and yield.
Used in Specialty Chemicals Production:
Tert-butyl-methoxy-dimethylsilane is also used in the creation of specialty chemicals, which are tailored for specific applications in various industries, such as coatings, adhesives, and materials science.
Used in Research and Development Laboratories:
In research settings, this compound is a valuable tool for exploring new synthetic pathways and developing innovative chemical processes, further expanding the horizons of chemical science and technology.

Upstream product

• 53172-91-1 (benzyloxy)(tert-butyl)dimethylsilane 

Downstream Products

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 

Relevant articles and documents

Hafnium Triflate as a Highly Potent Catalyst for Regio- and Chemoselective Deprotection of Silyl Ethers

As a Group IVB transition metal Lewis acid, hafnium triflate [Hf(OTf) 4 ] exhibited exceptionally high potency in desilylations. Since the amounts of Hf(OTf) 4 required for the deprotection of 1°, 2°, 3° alkyl and aryl tert -butyldimethylsilyl (TBS) ethers are significantly different, ranging from 0.05 mol% to 3 mol%, regioselective deprotection of TBS could be easily implemented. Moreover, chemoselective cleavage of different silyl ethers or removal of TBS in the presence of most hydroxyl protecting groups was also accomplished. NMR analyses of silyl products from TBS deprotection indicated that Hf(OTf) 4 -catalyzed desilylation may proceed via different mechanisms, depending on the solvent used.