- (2,3-Dichloro-4-carboxy)phenoxy acetic acid and esters thereof
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2,3-Dichloro-4-(2-thenoyl)phenoxyacetic acid (tienilic acid) is prepared by reacting (2,3-dichloro-4-carboxy)phenoxyacetic acid with thiophene in the presence of a dehydration agent. The (2,3-dichloro-4-carboxy)phenoxyacetic acid is a novel compound.
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- Uricosuric composition and method of producing uricosuria and hypouricemia
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Uricosuric compositions containing 2,3-dichloro-4-carboxyphenoxyacetic acid or its alkali metal salts and methods of producing uricosuria and hypouricemia by administering said compounds.
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- 2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation thereof
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A Reimer-Tiemann reaction of 2,3-dichlorophenol with carbon tetrachloride gives 2,3-dichloro-4-hydroxy-benzoic acid, a novel intermediate, which is then reacted with thiophene in the presence of phosphorus pentoxide or polyphosphoric acid to give 2,3-dichloro-4-(2-thienoyl)-phenol. This compound is then converted to the diuretic, ticrynafen, by known prior art reactions.
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