- NOVEL IMINONITRILE DERIVATIVES
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The invention relates to a compound of formula (I) wherein X1 to X4 and RC to RG are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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- INHIBITORS OF THE KYNURENINE PATHWAY
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The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and phannaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.
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- PYRIDINE COMPOUNDS AND METHODS OF THEIR USE
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Novel pyridine compounds, pharmaceutical compositions containing the pyridine compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the pyridine compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.
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Page/Page column 72; 113
(2008/12/05)
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- Novel approach towards the synthesis of 3,3a,4,5-tetrahydroquinolino[4,3-c] isoxazole derivatives: Application to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole scaffolds
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A novel synthetic approach towards the preparation of 3-substituted-7,8- dimethoxy-3,3a,4,5-tetrahydroquinolino[4,3-c]isoxazole derivatives is reported. Further application of this methodology to the preparation of previously unattainable 3a,4-dihydroazab
- Alcázar, Jesús,Alonso, José Manuel,Andrés, José Ignacio,Bartolomé, José Manuel,Fernández, Javier
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p. 3139 - 3141
(2007/10/03)
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- FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS
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The invention concerns fused heterocyclic isoxazoline derivatives of Formula (I), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof, more in particular, tetrahydro
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