666828-90-6

Basic information

• Product Name: 1H-Indol-1-amine,5-fluoro-(9CI)
• Synonyms: 1H-Indol-1-amine,5-fluoro-(9CI)
• CAS NO: 666828-90-6
• Molecular Formula: C₈H₇FN₂
• Molecular Weight: 150.155
• Product Categories: INDOLE;AMINEPRIMARY;HALIDE
• Mol File: 666828-90-6.mol

Chemical Properties

• Boiling Point: 300.9±34.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• PKA: 6.07±0.70(Predicted)
• CAS DataBase Reference: 1H-Indol-1-amine,5-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indol-1-amine,5-fluoro-(9CI)(666828-90-6)
• EPA Substance Registry System: 1H-Indol-1-amine,5-fluoro-(9CI)(666828-90-6)

Safety Data

• Hazardous Substances Data: 666828-90-6(Hazardous Substances Data)

Upstream product

• 399-52-0 5-fluoro-1H-indole 

Downstream Products

• 1068969-71-0 2-phenyl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide 
• 1068970-28-4 2-(3-fluorophenyl)-4-methylpyrimidine-5-carboxylic acid (5-fluoroindol-1-yl)amide 
• 1068970-04-6 2-(3-fluorophenyl)pyrimidine-5-carboxylic acid (5-fluoroindol-1-yl)amide 
• 1068970-85-3 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (3-chloro-5-fluoro-indol-1-yl)-amide 
• 1068975-13-2 5-fluoro-1-{[2-(3-fluorophenyl)pyrimidine-5-carbonyl]amino}-1H-indole-3-sulfonyl chloride 
• 1068968-60-4 2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid (3-cyano-5-fluoro-indol-1-yl)-amide 
• 1068968-31-9 2-(3-fluorophenyl)pyrimidine-5-carboxylic acid (5-fluoro-3-sulfamoylindol-1-yl)amide 
• 1068975-17-6 5-fluoro-1-{[2-(3-fluorophenyl)-4-methylpyrimidine-5-carbonyl]amino}-1H-indole-3-sulfonyl chloride 
• 1068975-16-5 5-fluoro-1-{[2-(3-fluorophenyl)-4-methylpyrimidine-5-carbonyl]amino}-1H-indole-3-sulfonic acid 
• 1068970-87-5 5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide 
• 1068968-63-7 2-(3-fluoro-phenyl)-4-methylpyrimidine-5-carboxylic acid [5-fluoro-3-(1H-tetrazol-5-yl)-indol-1-yl]-amide 

Relevant articles and documents

1-[(Imidazolidin-2-yl)imino]-1H-indoles as new hypotensive agents: synthesis and in vitro and in vivo biological studies

A series of 1-[(imidazolidin-2-yl)imino]-1H-indole analogues of hypotensive α2-AR agonists, 1-[(imidazolidin-2-yl)imino]-1H-indazoles, was synthesized and tested in vitro for their activities at α1- and α2-adrenoceptors as well as imidazoline I1 and I2 receptors. The most active 1-[(imidazolidin-2-yl)imino]-1H-indoles displayed high or moderate affinities for α1- and α2-adrenoceptors and substantial selectivity for α2-adrenoceptors over imidazoline-I1 binding sites. The in vivo cardiovascular properties of indole derivatives 3 revealed that substitution at C-7 position of the indole ring may result in compounds with high cardiovascular activity. Among them, 7-fluoro congener 3g showed the most pronounced hypotensive and bradycardic activities in this experiment at a dose as low as 10?μg/kg i.v. Metabolic stability of the selected compounds of type 3 was determined using both in vitro and in silico approaches. The results indicated that these compounds are not vulnerable to rapid first-phase oxidative metabolism.

1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds

Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom,R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond,R1, R2, R3 and R4 represent a hydrogen or halogen atom,an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups,R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group,X and Y represent a hydrogen atom or an alkyl group,Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain,Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.

PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS

This invention is directed to a compound wherein R1, R2, R3, R4 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or

N-Amination of Pyrrole and Indole Heterocycles with Monochloramine (N H2Cl)

A survey of several electrophilic ammonia reagents for the N-amination of indole- and pyrrole-containing heterocycles revealed that monochloramine (NH2Cl) is an excellent reagent for this transformation. Pyrroles and indoles containing a variety of substitution were aminated on nitrogen with isolated yields ranging from 45% to 97%.