QUATERNARY LACTAM COMPOUND AND PHARMACEUTICAL USE THEREOF
A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders.
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(2021/02/05)
RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE
Provided herein are compounds as RORγ antagonist having Formula (I). The compounds or pharmaceutical composition thereof can be used for regulating Retinoid-related orphan receptor gamma t (RORγt). Also provided herein are methods of preparation of the compounds and composition thereof, and uses thereof in treating or preventing RORγt mediated inflammation or autoimmune diseases in mammals, particularly humans.
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Paragraph 00551
(2020/02/06)
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