- Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature
-
Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.
- Kandasamy, Jeyakumar,Lee, Yong Rok,Singh, Adesh Kumar,Venkatesh, Rapelly
-
supporting information
p. 7832 - 7837
(2021/09/28)
-
- Synthesis of Substrates for Aldolase-Catalysed Reactions: A Comparison of Methods for the Synthesis of Substituted Phenylacetaldehydes
-
Methods for the synthesis of phenylacetaldehydes (oxidation, one-carbon chain extension) were compared by using the synthesis of 4-methoxyphenylacetaldehyde as a model example. Oxidations of 4-methoxyphenylethanol with activated DMSO (Swern oxidation) or manganese dioxide gave unsatisfactory results; whereas oxidation with 2-iodoxybenzoic acid (IBX) produced 4-methoxyphenylacetaldehyde in reasonable (75%) yield. However, Wittig-type one-carbon chain extension with methoxymethylene-triphenylphosphine followed by hydrolysis gave an excellent (81% overall) yield of 4-methoxyphenylacetaldehyde from 4-methoxybenzaldehyde (a cheap starting material). This approach was subsequently used to synthesise a set of 10 substituted phenylacetaldehydes in good to excellent yields.
- Al-Smadi, Derar,Enugala, Thilak Reddy,Norberg, Thomas,Kihlberg, Jan,Widersten, Mikael
-
supporting information
p. 1187 - 1190
(2018/03/26)
-
- Berberine derivative and use thereof
-
The invention discloses a berberine derivative for treating bacterium infection, and a use for thereof. The berberine derivative has a structure shown in the description. Experiments prove that the berberine derivative has positive ion charges under physiological conditions, and has the characteristics of broad antibacterial spectrum, good biocompatibility, good water solubility, strong targetingand low toxicity, a preparation method has the advantages of simplicity, easiness in implementing, high yield, and significant curative effect in the antibacterial field.
- -
-
Paragraph 0047; 0096-0097
(2018/06/15)
-
- Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing
-
A methodology is reported for the preparation of various aromatic-functionalized vinyl ethers using a Wittig approach. The subsequent hydrogenation of the vinyl ether products to their saturated analogs is also performed and is streamlined by employing continuous-flow processing.
- Balti, Monaem,Efrit, Mohamed Lotfi,Leadbeater, Nicholas E.
-
supporting information
p. 1804 - 1806
(2016/04/05)
-
- Enol ethers as carbonyl surrogates in a modification of the Povarov synthesis of 3-aryl quinolines and their anti-Toxoplasma activity
-
A novel method for the preparation of 2-carboxyl-3-aryl quinoline derivatives from anilines, ethyl glyoxalate and enol ethers as phenylacetaldehyde surrogates is reported. The three-component coupling reaction occurs rapidly under mild conditions in dichl
- Brown, Carla E.,McNulty, James,Bordón, Claudia,Yolken, Robert,Jones-Brando, Lorraine
-
supporting information
p. 5951 - 5955
(2016/07/06)
-
- I2-catalyzed regioselective oxo- and hydroxy-acyloxylation of alkenes and enol ethers: A facile access to α-acyloxyketones, esters, and diol derivatives
-
I2-catalyzed oxo-acyloxylation of alkenes and enol ethers with carboxylic acids providing for the high yield synthesis of α-acyloxyketones and esters is described. This unprecedented regioselective oxidative process employs TBHP and Et3/s
- Reddi, Rambabu N.,Prasad, Pragati K.,Sudalai, Arumugam
-
supporting information
p. 5674 - 5677
(2015/02/19)
-
- Mizoroki-Heck and Sonogashira cross-couplings catalyzed by CNC palladium pincer complexes in organic and aqueous media
-
The catalytic activity of two CNC palladium pincer complexes is evaluated in two fundamental C - C bond-forming reactions: Mizoroki - Heck and Sonogashira cross-couplings. After several optimization attempts and a brief comparison with a PCN pincer cataly
- SanMartin, Raul,Ines, Blanca,Moure, Maria Jesus,Herrero, Maria Teresa,Dominguez, Esther
-
experimental part
p. 955 - 962
(2012/08/08)
-
- Rhodium-catalyzed anti-Markovnikov intermolecular hydroalkoxylation of terminal acetylenes
-
We report here the first transition-metal-catalyzed anti-Markovnikov intermolecular hydroalkoxylation of terminal acetylenes to give enol ethers in high yields without using bases. Arylacetylenes as well as alkenyl- and alkylacetylenes were coupled with aliphatic alcohols, and the products were obtained with high Z selectivity in most cases. Effective catalysts were 8-quinolinolato rhodium complexes, which are structurally simple but have been relatively unexplored as catalysts.
- Kondo, Masataka,Kochi, Takuya,Kakiuchi, Fumitoshi
-
supporting information; experimental part
p. 32 - 34
(2011/03/16)
-
- Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group
-
A series of new structural benzoylphenylureas (BPUs) containing oxime ether and oxime ester group were designed and synthesized. The larvicidal activities against Oriental armyworm and mosquito of these benzoylphenylureas were evaluated and the result of bioassay displayed specific structure-activity relationship (SAR). Most of the compounds exhibited excellent larvicidal activities against Oriental armyworm and mosquito. Interestingly, some compounds showed different structure-activity relationship towards diamondback moth, beet armyworm, and corn borer although three tested insects all belong to the same insect order.
- Sun, Ranfeng,Li, Yongqiang,Lue, Maoyun,Xiong, Lixia,Wang, Qingmin
-
supporting information; experimental part
p. 4693 - 4699
(2010/10/02)
-
- Microwave-assisted in situ deprotection and ω-methoxylation of TMS-protected aryl alkynes
-
Using microwave technology, rapid ω-methoxylation of aryl alkynes is possible.
- Wettergren, Jenny,Minidis, Alexander B. E.
-
p. 7611 - 7612
(2007/10/03)
-
- Ferrocenyl derivatives with one, two, or three sulfur-containing arms for self-assembled monolayer formation
-
Self-assembled monolayers of electroactive molecules can form on gold electrodes if the molecules include a sulfur-containing group to coordinate with the gold surface. We have prepared a molecule with a tripod of sulfur groups that has the potential of fixing the geometry of the molecule relative to the gold surface. The target (3) contained the good one-electron donor ferrocene connected through a benzene spacer to an isobutane tripod, with each arm of the tripod ending in a methylthio group. Analogous compounds with one (1) and two (2) coordinating arms were also prepared.
- Hu, Jian,Mattern, Daniell Lewis
-
p. 2277 - 2281
(2007/10/03)
-
- Palladium on Charcoal-catalysed Arylation of Methyl Vinyl Ether with 4-Bromonitrobenzene
-
Palladium on charcoal has been used as a catalyst in the reaction of 4-bromonitrobenzene with methyl vinyl ether to give the desired (E)- and (Z)-methyl 2-p-nitrophenylvinyl ether.In addition, methyl 1-p-nitrophenyl ether, isolated as 4-nitroacetophenone,
- Hallberg, Anders,Westfelt, Lars
-
p. 933 - 935
(2007/10/02)
-