669713-77-3

Basic information

• Product Name: 2-BIPHENYL-2'-CHLORO-ACETIC ACID
• Synonyms: 2'-Chloro-biphenyl-2-acetic acid
• CAS NO: 669713-77-3
• Molecular Formula: C14H11ClO2
• Molecular Weight: 246.692
• Mol File: 669713-77-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BIPHENYL-2'-CHLORO-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BIPHENYL-2'-CHLORO-ACETIC ACID(669713-77-3)
• EPA Substance Registry System: 2-BIPHENYL-2'-CHLORO-ACETIC ACID(669713-77-3)

Safety Data

• Hazardous Substances Data: 669713-77-3(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
2-BIPHENYL-2'-CHLORO-ACETIC ACID is used as a selective herbicide enhancer for phenoxy-carboxylic acid herbicides. It contributes to the effectiveness of these herbicides by potentially inhibiting the enzyme acetolactate synthase in plants, which disrupts the production of branched-chain amino acids and leads to plant death.
Used in Pharmaceutical Industry:
2-BIPHENYL-2'-CHLORO-ACETIC ACID is used as a potential antibacterial agent. It has shown activity against certain bacterial strains, indicating its potential use in the development of new antibacterial medications to combat resistant infections.

Upstream product

• 3900-89-8 2-Chlorobenzeneboronic acid 
• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 

Relevant articles and documents

Identification of 2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide as a Sodium Valproate-like broad spectrum anti-epileptic drug candidate

By further optimizing compound A [2′-fluoro-N-methyl-[1,1′-biphenyl]-2-sulfonamide], we identified DSP-0565 [2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide, 17a] as a strong, broad-spectrum anti-epileptic drug (AED) candidate. Our efforts mainly focused on finding an alternative polar group for the sulfonamide in order to improve ADME profile of compound A including good metabolic stability and no reactive metabolic production. This led to the identification of biphenyl acetamide as a new scaffold for development of broad-spectrum AED candidates. DSP-0565 showed anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin, and was therefore selected as a clinical candidate.

BIPHENYLACETAMIDE DERIVATIVE

The present invention provides a compound of formula (I) or a salt thereof, wherein R1, R2 and R3 are independently selected from the group consisting of hydrogen atom, fluorine atom, chlorine atom, bromine atom, C1-6 alkyl, C1-6 alkoxy substituted with fluorine atom, and others; R4 and R5 are independently selected from the group consisting of hydrogen atom, fluorine atom, chlorine atom, C1-6 alkyl, C1-6 alkoxy substituted with fluorine atom, and others; R6 and R7 are independently selected from the group consisting of hydrogen atom, fluorine atom, methyl, ethyl, hydroxy group, and others; and R8 and R9 are independently selected from the group consisting of hydrogen atom, C1-6 alkyl, and others, which is useful as an agent for treating or preventing various types of epilepsy including partial seizures and/or generalized seizures.