669732-39-2

Basic information

• Product Name: N-(4-bromo-3-methylphenyl)ethanesulfonamide
• Synonyms: N-(4-bromo-3-methylphenyl)ethanesulfonamide
• CAS NO: 669732-39-2
• Molecular Formula: C9H12BrNO2S
• Molecular Weight: 278.16608
• Mol File: 669732-39-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-bromo-3-methylphenyl)ethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-3-methylphenyl)ethanesulfonamide(669732-39-2)
• EPA Substance Registry System: N-(4-bromo-3-methylphenyl)ethanesulfonamide(669732-39-2)

Safety Data

• Hazardous Substances Data: 669732-39-2(Hazardous Substances Data)

Upstream product

• 6933-10-4 amino-5-bromo-2-toluene 
• 594-44-5 Ethanesulfonyl chloride 

Relevant articles and documents

Synthesis of CF3CH2-Containing Indolines by Transition-Metal-Free Aryltrifluoromethylation of Unactivated Alkenes

With an unactivated double bond as the radical acceptor, allyl amines underwent a metal-free trifluoromethylation/cyclization cascade with CF3SO2Na (Langlois' reagent), affording CF3CH2-containing indolines and tetrahydroisoquinolines, whose practical syntheses are significant challenges. This protocol features mild conditions, low cost, and a broad substrate scope.

Synthetic method of CF3-containing indoline and 1,2,3,4-tetrahydroisoquinoline

The invention discloses a synthetic method of CF3-containing indoline and 1,2,3,4-tetrahydroisoquinoline and relates to the technical field of compound synthesis. The synthetic method herein is basedon metal-free trifluoromethylation/cyclization free radical cascade reaction using a nonactive olefin dual-bond as a free radical receptor; the reaction aforementioned helps synthesize, in one step, CF3-containing indoline and 1,2,3,4-tetrahydroisoquinoline. The synthetic method herein has the significant advantages of mild conditions, good operational simplicity, low cost, wide substrate range, good exo selectivity and the like.