This invention is directed toward pharmacologically active compounds of the formula STR1 wherein R represents a hydrogen atom or a lower alkyl group and R1 represents a hydrogen or halogen atom or a trifluoromethyl group which have the absolute configuration S at the 3-position carbon atom. Also presented is a process to produce the above benzodiazepine derivatives and pharmaceutical preparations therefor. The above benzodiazepine derivatives exhibit pronounced anthelmintic, especially schistosomicidal, activity and muscle relaxant, anticonvulsant and sedative activities.
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(2008/06/13)
Benzodiazepine derivatives
This invention is directed to pharmacologically active compounds of the formula STR1 wherein R1 represents a hydrogen atom or lower alkyl group and R2 represents a halogen atom. The compounds of formula I are optically active and have the absolute configuration S at the carbon atom in the 3-position. They exhibit anthelmintic, sedative, anticonvulsant and muscle relaxant activity. Also provided are methods for their preparation and formulations which incorporate the active compounds.
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(2008/06/13)
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