N-Alkyl carbamates of primary amines are easily converted into amides under treatment with Grignard reagents. Consequently, primary amines can be converted into amides in a one-pot reaction through carbamate protection and Grignard addition.
Latorre, Antonio,Rodríguez, Santiago,Izquierdo, Javier,González, Florenci V.
experimental part
p. 2653 - 2655
(2009/08/09)
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