67249-24-5Relevant articles and documents
AMIDOETHYL AZOLE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 34-35, (2016/07/27)
An amidoethyl azole compounds are provided as antagonists of orexin receptors. The compounds may be used for treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.
CHEMICAL COMPOUNDS
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Page/Page column 48, (2012/02/15)
The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.
Synthesis of two metabolites of the antiarrythmicum amiodarone
Wendt, Barbara,Ha, Huy Riem,Hesse, Manfred
, p. 2990 - 3001 (2007/10/03)
The metabolism of the potent antiarrythmic drug amiodarone (AMI; 1) has yet not been fully investigated. Recently, in vitro experiments revealed that in rabbit-liver microsomes, AMI (1) and its main metabolite MDEA (2) were biotransformed to the hydroxyla
SYNTHESIS AND USE OF BENZYL TERT-BUTYL IMINODICARBONATE, A VERSATILE REAGENT FOR THE PREPARATION OF AMINES
Grehn, Leif,Ragnarsson, Ulf
, p. 2778 - 2786 (2007/10/02)
An efficient synthesis of benzyl tert-butyl iminodicarbonate (IV), starting from benzoyl isocyanate, is reported.Reaction of the isocyanate with benzyl alcohol gave benzyl N-benzoylcarbamate (II) which on exhaustive tert-butoxycarbonylation via the non-isolated triacyl amine III, after aminolysis, provided the title compound.The sodium salt V was alkylated with various halides under Gabriel conditions to give in high yields the corresponding benzyloxycarbonyl tert-butoxycarbonyl diprotected amines.Similarly, compound IV was alkylated with alcohols under Mitsunobu conditions to give some additional amines of this type, from which the protecting groups can be removed selectively under mild conditions.