Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles
A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole was selected for further study. A comparison of this compound with phenylbutazone and tiaramide revealed that it possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.
Tsukamoto,Yoshino,Kohno,Ohtaka,Kagaya,Ito
p. 734 - 738
(2007/10/02)
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