Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein
Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.
MECHANISMUS DER REAKTION VON TRIARYLPHOSPHITEN MIT PHOSPHORSAEUREN
Arylation of diethyl phosphoric acid by triphenylphosphite leading to diethylphenylphosphate was studied by NMR-spectroscopy.The mixed PIII-PIV-anhydride was proved to be an intermediate.The scope of arylation is presented.
Markowska, A.,Olejnik, J.,Mlotkowska, B.,Sobanska, M.
p. 143 - 146
(2007/10/02)
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