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3-ethynylpyridin-2-amine, a chemical compound with the molecular formula C8H6N2, is a pyridine derivative featuring an ethynyl group and an amine group attached to the second carbon of the pyridine ring. This versatile molecule is widely utilized in organic synthesis and chemical research, serving as a fundamental building block for constructing more complex molecules. Its unique structure and reactivity have garnered interest in the pharmaceutical, agrochemical, and materials science fields, where it is studied for its potential pharmacological properties, including its capacity to function as a ligand for various receptors and enzymes in the human body.

67346-74-1

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67346-74-1 Usage

Uses

Used in Organic Synthesis:
3-ethynylpyridin-2-amine is used as a key intermediate in organic synthesis for the creation of a variety of complex organic molecules. Its ethynyl and amine functional groups provide opportunities for further chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
In the realm of chemical research, 3-ethynylpyridin-2-amine is employed as a model compound to study the reactivity and properties of pyridine derivatives. Its unique structure allows researchers to explore new reaction pathways and mechanisms, contributing to the advancement of synthetic chemistry.
Used in Pharmaceutical Development:
3-ethynylpyridin-2-amine is used as a potential pharmacological agent in the development of new drugs. Its ability to act as a ligand for various receptors and enzymes in the human body makes it a promising candidate for the treatment of various diseases and conditions. Researchers are investigating its potential therapeutic applications, including its use in the development of novel drugs with improved efficacy and selectivity.
Used in Agrochemical Production:
In the agrochemical industry, 3-ethynylpyridin-2-amine is utilized as a building block for the synthesis of new pesticides and other crop protection agents. Its unique structure and reactivity enable the development of innovative agrochemicals with enhanced performance and selectivity, contributing to more effective and sustainable agricultural practices.
Used in Materials Science Applications:
3-ethynylpyridin-2-amine is also employed in materials science for the development of new materials with specific properties. Its ethynyl and amine groups can be incorporated into the design of advanced materials, such as conductive polymers, sensors, and other functional materials, with potential applications in various industries, including electronics, energy, and environmental protection.

Check Digit Verification of cas no

The CAS Registry Mumber 67346-74-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,3,4 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 67346-74:
(7*6)+(6*7)+(5*3)+(4*4)+(3*6)+(2*7)+(1*4)=151
151 % 10 = 1
So 67346-74-1 is a valid CAS Registry Number.

67346-74-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-ethynylpyridin-2-amine

1.2 Other means of identification

Product number -
Other names 2-PYRIDINAMINE,3-ETHYNYL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67346-74-1 SDS

67346-74-1Relevant articles and documents

NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY

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Page/Page column 47, (2020/01/24)

The present invention relates to bicyclic compounds (e.g. indoles) containing a sulfonyl moiety, which bind to the liver X receptor (LXRα and/or LΧΚβ) and act preferably as inverse agonists of LXR.

Copper-Catalyzed Tandem Cross-Coupling/[2 + 2] Cycloaddition of 1,6-Allenynes with Diazo Compounds to 3-Azabicyclo[5.2.0] Ring Systems

He, Min,Chen, Nuan,Zhou, Ting,Li, Qing,Li, Hongguang,Lang, Ming,Wang, Jian,Peng, Shiyong

, p. 9559 - 9563 (2019/11/21)

An unprecedented copper-catalyzed tandem cross-coupling/[2 + 2] cycloaddition of 1,6-allenynes with diazo compounds was reported, chemo- and regioselectively providing 3-azabicyclo[5.2.0] frameworks in moderate to excellent yields under mild reaction conditions. Moreover, the products readily convert to highly functionalized quinolines via oxidative radical rearrangement.

One-Pot Access to Benzo[a]carbazoles via Palladium(II)-Catalyzed Hetero- and Carboannulations

Jash, Moumita,Das, Bimolendu,Chowdhury, Chinmay

, p. 10987 - 10999 (2016/11/28)

A Pd(II)-catalyzed direct synthesis of benzo[a]carbazoles has been achieved through aminopalladation of alkynes, followed by intramolecular nucleophilic addition of the generated carbon-palladium bond to a tethered cyano/aldehyde group. Compared to literature procedures, this synthetic approach is operationally simple, uses simple substrates, and offers a fast intramolecular assembly resulting in the direct synthesis of benzo[a]carbazoles in which a wide variation of substituents at different sites is well-tolerated, leaving enough opportunity for diversification.

Copper-catalyzed [5 + 1] annulation of 2-ethynylanilines with an N, O -acetal leading to construction of quinoline derivatives

Sakai, Norio,Tamura, Kosuke,Shimamura, Kazuyori,Ikeda, Reiko,Konakahara, Takeo

supporting information; experimental part, p. 836 - 839 (2012/04/05)

A novel copper-catalyzed [5 + 1] annulation of 2-ethynylanilines with an N,O-acetal, which functioned as a C1 part, leading to the preparation of quinoline derivatives with an ester substituent on the 2-position is described. A combination of CuBr2/

COMPOSITION FOR AGRICULTURAL USE

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, (2011/08/04)

Provided is an agricultural composition comprising a compound represented by the formula (I) or a salt thereof or a hydrate thereof, for controlling a plant disease due to a plant pathogen: [wherein, G represents a di-valent aromatic hetero 5-membered rin

PYRIDINE DERIVATIVE CONTAINING ((PHOSPHONOOXY)METHYL)PYRIDINIUM RING, AND ANTIFUNGAL AGENT CONTAINING THESE DERIVATIVE

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Page/Page column 11, (2011/01/05)

The present invention provides an antifungal agent that has excellent antifungal action, and is also superior in terms of its properties, and particularly its solubility in water and safety in an aqueous solution, and its in vivo pharmacokinetics and safety. According to the present invention, there is provided a compound represented by the following formula (I), or a salt thereof: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 alkoxy C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group, or a di-C1-6 alkylamino group;R3 represents a hydrogen atom, a halogen atom, or a C1-6 alkyl group; andR4 represents a hydrogen atom, a halogen atom, or a C1-6 alkyl group.

Single bifunctional ruthenium catalyst for one-pot cyclization and hydration giving functionalized indoles and benzofurans

Nair, Reji N.,Lee, Paul J.,Rheingold, Arnold L.,Grotjahn, Douglas B.

supporting information; experimental part, p. 7992 - 7995 (2010/09/18)

Chemical equation Presented Bifunctional is more than twice as fun! At low loading, catalyst 1 (see scheme) can form two important heterocycle classes, apparently by attack of XH on a vinylidene intermediate. Aza- and nitroindoles can be formed, and all N-protecting groups tested (alkyl, allyl, sulfonyl) were tolerated. The newly formed ring can be deuterated in one step, and for substrates with two terminal alkynes, cyclization can be followed by hydration, making this catalyst uniquely versatile.

SPIROAMINODIHYDROTHIAZINE DERIVATIVES

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Page/Page column 102, (2010/04/03)

A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer- type dementia.

PYRIDINE DERIVATIVES SUBSTITUTED BY HETEROCYCLIC RING AND PHOSPHONOAMINO GROUP, AND ANTI-FUNGAL AGENT CONTAINING SAME

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Page/Page column 51-52, (2009/04/24)

Anti-fungal agent having excellent anti-fungal action physicochemical properties including safety and water solubility. Compound represented by formula (I), or salt thereof: wherein R1 represents hydrogen, halogen, amino, R11-NH- wherein R11 represents C1-6 alkyl, hydroxy C1-6 alkyl, C1-6 alkoxy C1-6 alkyl, or C1-6alkoxycarbonyl C1-6 alkyl, R12-(CO)-NH- wherein R12 represents C1-6 alkyl group or C1-6 alkoxy C1-6 alkyl, C1-6 alkyl, hydroxy C1-6 alkyl, cyano C1-6 alkyl, C1-6 alkoxy, or C1-6 alkoxy C1-6 alkyl or a phosphonoamino group; R2 represents hydrogen, C1-6 alkyl, amino, or a di C1-6 alkylamino group or a phosphonoamino group; one of X and Y is nitrogen while the other is nitrogen or oxygen; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, oxygen, sulfur, -CH2O-, -OCH2-, -NH-, -CH2NH-, -NHCH2-, -CH2S-, or -SCH2-; R3 represents hydrogen or halogen or C1-6 alkyl, C3-8 cycloalkyl, C6-10 aryl, a 5- or 6-member heteroaryl group or a 5- or 6-member nonaromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents hydrogen or halogen; provided that either R1 or R2 represents a phosphonoamino group.

PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROARYL RING, AND ANTIFUNGAL AGENT COMPRISING THE SAME

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Page/Page column 59, (2009/06/27)

The present invention provides an antifungal agent that has excellent antifungal action, and is also excellent in terms of its properties, safety, and metabolic stability. The present invention discloses a compound represented by the following formula I or a salt thereof, and an antifungal agent comprising the compound or the salt: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6-alkoxy-C1-6-alkyl group; R2 represents a hydrogen atom or an amino group; X, Y, Z, and W independently represent a nitrogen atom, an oxygen atom, a sulfur atom, or -CH-, provided that at least two among X, Y, and W are nitrogen atoms; the ring A represents a 5- or 6-membered heteroaryl ring or a benzene ring; Q represents a methylene group, an oxygen atom, -CH2O-, -OCH2-, -NH-, -NHCH2-, or -CH2NH-; and R3 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, or a 5- or 6-membered heteroaryl group, each of which may have one or two substituents.

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