67452-97-5

Basic information

• Product Name: Vaderm
• Synonyms: Alclometasone;Vaderm;ALCLOMETHASONE DIPROPIONATE;7α-Chloro-16α-methylprednisolone;7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione;AlcloMethasone
• CAS NO: 67452-97-5
• Molecular Formula: C22H29ClO5
• Molecular Weight: 408.919
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids
• Mol File: 67452-97-5.mol

Chemical Properties

• Melting Point: 176-179°
• Boiling Point: 607.1°Cat760mmHg
• Flash Point: 320.9°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 2.85E-17mmHg at 25°C
• Refractive Index: 1.607
• PKA: 12.30±0.70(Predicted)
• CAS DataBase Reference: Vaderm(CAS DataBase Reference)
• NIST Chemistry Reference: Vaderm(67452-97-5)
• EPA Substance Registry System: Vaderm(67452-97-5)

Safety Data

• Hazardous Substances Data: 67452-97-5(Hazardous Substances Data)

Usage

Uses

Used in Dermatology:
Vaderm is used as a topical agent for various skin conditions due to its anti-inflammatory, antipruritic, antiallergic, antiproliferative, and vasoconstrictive properties. It helps in reducing inflammation, itching, and allergic reactions, as well as controlling the growth of skin cells and constricting blood vessels.
Used in Pharmaceutical Industry:
As a metabolite of Alclometasone dipropionate (A514580), Vaderm plays a significant role in the development of synthetic glucocorticoid steroids for medical use. It is an essential component in the formulation of various dermatological medications, contributing to their effectiveness in treating skin conditions.
Brand Name:
Aclovate (GlaxoSmithKline) is a brand name under which Vaderm is marketed, making it easily recognizable and accessible to patients and healthcare professionals.

InChI:InChI=1/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1

Upstream product

• 66734-13-2 alclometasone dipropionate 

Relevant articles and documents

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The influence of esterification on the topical antiinflammatory activity of 7α-chloro- and 7α-bromo-16α-methylprednisolones

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7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor

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