675590-28-0

Basic information

• Product Name: 3-BROMO-5-(P-TOLYL)PYRIDINE
• Synonyms: 3-BROMO-5-(P-TOLYL)PYRIDINE;3-Bromo-5-(4-methylphenyl)pyridine
• CAS NO: 675590-28-0
• Molecular Formula: C₁₂H₁₀BrN
• Molecular Weight: 248.12
• Mol File: 675590-28-0.mol

Chemical Properties

• Boiling Point: 321.1 °C at 760 mmHg
• Flash Point: 148 °C
• Appearance: /
• Density: 1.375
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BROMO-5-(P-TOLYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-(P-TOLYL)PYRIDINE(675590-28-0)
• EPA Substance Registry System: 3-BROMO-5-(P-TOLYL)PYRIDINE(675590-28-0)

Safety Data

• Hazardous Substances Data: 675590-28-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Bromo-5-(p-tolyl)pyridine is used as a key intermediate in the synthesis of a wide range of organic compounds. Its unique structure, which includes a bromine atom and a phenyl ring attached to a pyridine nucleus, allows for versatile chemical reactions and transformations, making it a valuable building block in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Bromo-5-(p-tolyl)pyridine is utilized as a starting material for the development of new drugs. Its chemical structure can be further modified and functionalized to produce potential drug candidates with desired therapeutic properties. 3-BROMO-5-(P-TOLYL)PYRIDINE's reactivity and structural diversity make it a promising candidate for the synthesis of novel molecules with potential applications in various therapeutic areas, such as anti-inflammatory, analgesic, or antimicrobial agents.
Used in Agrochemical Industry:
3-Bromo-5-(p-tolyl)pyridine is also employed in the agrochemical industry as a precursor for the synthesis of various agrochemical products, such as pesticides and herbicides. Its chemical versatility enables the development of new compounds with improved efficacy, selectivity, and reduced environmental impact. 3-BROMO-5-(P-TOLYL)PYRIDINE's potential to be modified and optimized for specific applications makes it a valuable asset in the search for more effective and sustainable agrochemical solutions.

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 5142-75-6 tri(p-tolyl)bismuth 
• 5720-05-8 4-methylphenylboronic acid 

Relevant articles and documents

Unified Protocol for Cobalt-Catalyzed Oxidative Assembly of Two Aryl Metal Reagents Using Oxygen as an Oxidant

The first cobalt-catalyzed oxidative cross-coupling reaction of two aryl metal reagents is described. An equivalent amount of two aryl Grignard or lithium reagents, after mediation by an equivalent amount of simple ClTi(OEt)3, was facilely assembled under the catalysis of 1 mol % of CoCl2/10 mol % of DMPU using oxygen. The cross-couplings between various aryl metal reagents, especially between two structurally similar aryl Grignard reagents, proceeded smoothly and selectively and, thus, provided a highly general and efficient method for the construction of biaryl compounds.

Triarylbismuthanes as threefold aryl-transfer reagents in regioselective cross-coupling reactions with bromopyridines and quinolines

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalysed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both symmetrical and unsymmetrical diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalysed conditions. Copyright

Selective Suzuki-Miyaura monocouplings with symmetrical dibromoarenes and aryl ditriflates for the one-pot synthesis of unsymmetrical triaryls

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Controlled monoarylation of dibromoarenes in water with a polymeric palladium catalyst

A highly selective monoarylation of dibromoarenes was performed via the Suzuki-Miyaura cross-coupling with arylboronic acids with an amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin-supported phosphine-palladium complex in water under heteroge

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