NOVEL BIPHENYL DERIVATIVE COMPOUND AND USE THEREOF
The present disclosure provides a novel biphenyl derivative compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound, optical isomer thereof or pharmaceutically acceptable salt thereof according t
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Paragraph 0065-0066; 0081-0082
(2021/04/16)
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics
Leishmaniasis, a major health problem worldwide, has a limited arsenal of drugs for its control. The appearance of resistance to first- and second-line anti-leishmanial drugs confirms the need to develop new and less toxic drugs that overcome spontaneous
Borsari, Chiara,Jiménez-Antón, María Dolores,Eick, Julia,Bifeld, Eugenia,Torrado, Juan José,Olías-Molero, Ana Isabel,Corral, María Jesús,Santarem, Nuno,Baptista, Catarina,Severi, Leda,Gul, Sheraz,Wolf, Markus,Kuzikov, Maria,Ellinger, Bernhard,Reinshagen, Jeanette,Witt, Gesa,Linciano, Pasquale,Tait, Annalisa,Costantino, Luca,Luciani, Rosaria,Tejera Nevado, Paloma,Zander-Dinse, Dorothea,Franco, Caio H.,Ferrari, Stefania,Moraes, Carolina B.,Cordeiro-da-Silva, Anabela,Ponterini, Glauco,Clos, Joachim,Alunda, José María,Costi, Maria Paola
supporting information
(2019/09/30)
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