676486-29-6

Basic information

• Product Name: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-(9CI)
• Synonyms: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-(9CI)
• CAS NO: 676486-29-6
• Molecular Formula: C8H8N2
• Molecular Weight: 132.16252
• Product Categories: AMINETERTIARY
• Mol File: 676486-29-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-(9CI)(676486-29-6)
• EPA Substance Registry System: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-(9CI)(676486-29-6)

Safety Data

• Hazardous Substances Data: 676486-29-6(Hazardous Substances Data)

Upstream product

• 1192-58-1 N-methylpyrrole aldehyde 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 16640-68-9 cyanomethylene triphenylphosphorane 

Relevant articles and documents

Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells

T-cell acute lymphoblastic leukemia (T-ALL) is a hardly curable disease with a high relapse rate. 20 analogs were synthesized based on the structures of two kinds of fungi-derived polyenylpyrrole products (rumbrin (1) and auxarconjugatin-B (2)) to suppress the growth of T-ALL-derived cell line CCRF-CEM and tested for growth-inhibiting activity. The octatetraenylpyrrole analog gave an IC50 of 0.27 μM in CCRF-CEM cells, while it did not affect Burkitt lymphoma-derived cell line Raji and the cervical cancer cell line HeLa, or the oral cancer cell line HSC-3 (IC50 > 10 μM). This compound will be a promising compound for developing T-ALL-specific drugs.

2-(1-dimethylamino-2-cyanoethyl) pyrrole derivative and synthesis method thereof

The invention discloses a 2-(1-dimethylamino-2-cyanoethyl)pyrrole derivative and a synthesis method thereof. According to the method, a pyrrole derivative which is cheap, easy to obtain and diverse instructure is used as a raw material and is subjected to a Friedel-Crafts reaction with 3-dimethylaminoacrylonitrile in the presence of acid to synthesize the 2-(1-dimethylamino-2-cyanoethyl) pyrrolederivative. The method has the advantages of cheap and accessible raw materials, low toxicity, mild synthesis reaction conditions and high efficiency, and is simple to operate.

Rhodium(II) catalyzed intramolecular insertion of carbenoids derived from 2-pyrrolyl and 3-indolyl α-diazo-β-ketoesters and α-diazoketones

α-Diazo-β-ketoesters and α-diazoketones derived from 2-pyrrolylacetic, 2-pyrrolylpropionic, 3-indolylacetic and 3-indolylpropionic acids afforded carbenoid derived cyclization products on treatment with catalytic rhodium(II) acetate.

Utilisation of 13C N.M.R. Spectroscopy for the Identification of E- and Z-α,β-Unsaturated Esters, Ketones and Nitriles.

Measurement of 3JCO,H coupling constants provides an unambiguous procedure for the configurational analysis of substituted 2- and 3-arylpropenoic esters and of E- and Z-2-arylbut-2-en-1,4-dioates, even when only one of the isomers is available for analysis.An analogous procedure can also be used for the configurational analysis of 3-arylpropenonitriles and of 4-arylbut-3-en-2-ones.