676532-52-8

Basic information

• Product Name: 2-methyl-2-(1,2,4-trimethylpent-2-enoxy)propan-1-ol
• Synonyms: 1-propanol, 2-methyl-2-[(1,2,4-trimethyl-2-penten-1-yl)oxy]-; 2-[(3,5-Dimethylhex-3-en-2-yl)oxy]-2-methylpropan-1-ol
• CAS NO: 676532-52-8
• Molecular Formula: C₁₂H₂₄O₂
• Molecular Weight: 200.32
• EINECS: 614-096-2
• Mol File: 676532-52-8.mol

Chemical Properties

• Boiling Point: 270.8°C at 760 mmHg
• Flash Point: 93.5°C
• Density: 0.891g/cm³
• Vapor Pressure: 0.000877mmHg at 25°C
• Refractive Index: 1.452
• CAS DataBase Reference: 2-methyl-2-(1,2,4-trimethylpent-2-enoxy)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-(1,2,4-trimethylpent-2-enoxy)propan-1-ol(676532-52-8)
• EPA Substance Registry System: 2-methyl-2-(1,2,4-trimethylpent-2-enoxy)propan-1-ol(676532-52-8)

Safety Data

• Hazardous Substances Data: 676532-52-8(Hazardous Substances Data)

Upstream product

• 3132-13-6 3,5-dimethylhex-3-en-2-one 
• 66634-97-7 (E/Z)-2,4-dimethylpent-2-enoic acid 
• 558-30-5 2-methyl-1,2-epoxypropane 
• 676532-41-5 3,5-dimethylhex-3-en-2-ol 

Relevant articles and documents

Synthesis and Odor of Aliphatic Musks: Discovery of a New Class of Odorants

To find new aliphatic musks, we synthesized the propionates of 2-[1′-(3″,3″-dimethylcyclohex-1″-enyl)ethoxy] -2-methylpropanol (8), of 2-[1′-(5″,5″-dimethylcyclohex -1′-enyl)-ethoxy]-2-methylpropanol (11), of hydroxyacetic acid 1-(3′,3′-dimethylcyclohex-1′-enyl)ethyl ester (12), and of hydroxyacetic acid 1-(5′,5′-dimethylcyclohex-1′-enyl)ethyl ester (13) starting from 1-(3′,3′-dimethylcyclohex-1′ -enyl)-ethanone (5) and 1-ethynyl-3,3-dimethylcyclohexanol (9). We found that the 3,3-dimethylcyclohexenyl derivatives 8 (odor threshold 0.2 ng/air) and 12 (odor threshold 0.6 ng/air) are superior musk odorants, and, thus, we constructed 1,2,4-trimethylpent-2-enyloxy analogues as seco versions. The synthesis of the esters 17-26 commenced with a Wittig-Horner-Emmons reaction of isobutyric aldehyde (14), followed by saponification, alkylation with methyllithium, LAH reduction, etherification with isobutylene oxide, and Steglich esterification. (2″E)-2′-Methyl-2′-(1″,2″ ,4″-trimethylpent-2″-enyloxy)propyl cyclopropanecarboxylate [(2″E)-19], which has a powerful and sweet musk odor and slightly fruity nuances, was found to be a typical representative of this new class of musk odorants, was subjected to co conformational analysis. In addition, we report the synthesis and olfactory properties of the related ketones 28-30, the 2-methyl-2-(1′,4′,4′-trimethylpent-2′-enyloxy)propyl esters 31-33, and the 2-(1′,4′-dimethylpent-2′-enyloxy)-2- methylpropyl esters 35 and 36. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

ALIPHATIC COMPOUNDS AS FRAGRANTS WITH MUSK CHARACTERISTICS

This invention relates to aliphatic carbonyl compounds of formula I wherein, their manufacture and their use in fragrance compositions.[insert formula I here]R1 to R4, X and Y have the meaning as described in the specification