677743-50-9

Basic information

• Product Name: 2-Chloro-4-cyanophenylboronic acid
• Synonyms: 2-Chloro-4-cyanophenylboronic acid;(2-Chloro-4-cyanophenyl)
• CAS NO: 677743-50-9
• Molecular Formula: C₇H₅BClNO₂
• Molecular Weight: 181.3841
• Mol File: 677743-50-9.mol

Chemical Properties

• Boiling Point: 367.1±52.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.09±0.58(Predicted)
• CAS DataBase Reference: 2-Chloro-4-cyanophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-cyanophenylboronic acid(677743-50-9)
• EPA Substance Registry System: 2-Chloro-4-cyanophenylboronic acid(677743-50-9)

Safety Data

• Hazardous Substances Data: 677743-50-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-cyanophenylboronic acid is used as an intermediate in the synthesis of fused imidazole derivatives, which serve as TTK kinase inhibitors. These inhibitors are important for the development of targeted therapies against various diseases, including cancer, by modulating the activity of specific kinases involved in cell proliferation and survival pathways.
Additionally, 2-Chloro-4-cyanophenylboronic acid is utilized in the synthesis of pyrimidothiophenes, which act as HSP90 inhibitors. HSP90 (Heat Shock Protein 90) is a molecular chaperone that plays a crucial role in the stabilization and activation of various client proteins involved in signal transduction pathways. Inhibition of HSP90 can lead to the degradation of these proteins, thereby disrupting the cellular processes and potentially offering therapeutic benefits in the treatment of cancer and other diseases.

Downstream Products

• 1449475-62-0 (S)-tert-butyl (1-(6-(2-chloro-4-cyanophenyl)-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate