Iron(III) catalyzed halo-functionalization of alkynes
Abstract Aromatic and aliphatic alkynes can be halo-functionalized to α,α-dihalodimethyl ketals catalyzed by FeCl3 in excellent yields. MeOH is used as a nucleophilic solvent and N-halosuccinimide as the halogen source for this efficient transformation. The resulting α,α-dibromodimethyl ketals can be converted to the corresponding α,α-dibromoketones by treatment with 8% FeCl3 in silica gel.
Catano, Bryant,Lee, John,Kim, Claudia,Farrell, David,Petersen, Jeffrey L.,Xing, Yalan
supporting information
p. 4124 - 4127
(2015/08/03)
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