- A study of fragmentation of protonated amides of some acylated amino acids by tandem mass spectrometry: Observation of an unusual nitrilium ion
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A tandem mass spectrometric study of a series of secondary amides of acetylglycine and hippuric acid utilizing electrospray ionization (ESI) was conducted. Among the fragment ions observed was an unusual one, which we have determined to be a nitrilium ion
- Talaty, Erach R.,Young, Sarah M.,Dain, Ryan P.,Van Stipdonk, Michael J.
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experimental part
p. 1119 - 1129
(2012/03/26)
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- Aminothiazole derivative. I. A convenient synthesis of monocyclic and condensed 5-aminothiazole derivatives
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Treatment of diamides derived from α-amino acids with phosphorus pentasulfide or Lawesson's reagent was shown to provide a convenient method to prepare 5-aminothiazoles. By this method, in addition to monocyclic 5-aminothiazoles 19, novel bicyclic 5-aminothiazole derivatives such as 4,5,6,7-tetrahydrothiazolo[5,4-b]pyridines II, 5,6,7,8-tetrahydro-4H-thiazolo[5,4-b]azepines 7, 4,5,6,7,8,9-hexahydrothiazolo[5,4-b]azocine 16 and related compounds were prepared in moderate to good yields from simple diamides, suggesting the wide versatility of the method.
- Uchikawa,Fukatsu,Aono
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p. 877 - 887
(2007/10/02)
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