New method for the synthesis of diversely functionalized imidazoles from N-acylated α-aminonitriles
(Equation presented) A new general method for the synthesis of medicinally important diversely functionalized imidazoles from N-acylated α-aminonitriles has been developed. N-Acylated α-aminonitriles were reacted with triphenylphosphine and carbon tetrahalide to afford 2,4-disubstituted 5-halo-1H-imidazoles in good yield. This new methodology was applied for the synthesis of 2-butyl-4-chloro-5-hydroxymethylimidazole. These halo-imidazoles can be directly converted to 2,4,5-trisubstituted imidazoles through palladium-catalyzed coupling reactions.
Zhong, Yong-Li,Lee, Jaemoon,Reamer, Robert A.,Askin, David
p. 929 - 931
(2007/10/03)
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