68298-29-3

The invention discloses a synthetic method of propylene isopentoxy acetate perfume. According to the invention, a Williamson reaction is replaced, and ethyl diazoacetate and isoamyl alcohol are subjected to an O-H insertion reaction under the catalytic action of the catalyst Rh2(OAc)4 to synthesize propylene isopentoxy acetate, so reaction time is greatly shortened; in addition, the prepared solidacid catalyst Yb-MoO3/Al2O3-ZrO2 has the advantages easy separation from a liquid-phase reaction system, no corrosion to equipment and simple aftertreatment, overcomes the problems that conventionalliquid acid corrodes equipment and acid-containing wastewater pollutes environment, and also has high selectivity; the synthetic method can be carried out at low temperature, reduces energy consumption and side reactions, and greatly improves production efficiency; the yield of the prepared propylene isopentoxy acetate perfume is as high as 98.4%; the propylene isopentoxy acetate perfume has goodheat stability, small possibility of loss of active components and good repeated use performance, and is a novel green catalytic material with great application potential.

The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.

The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.

Sulfuric acid catalyzes the decarbonylation of alkoxyacetyl chlorides to produce the corresponding chloromethyl alkyl ethers in fairly good yields.