Optimization of methionyl tRNA-synthetase inhibitors for treatment of Cryptosporidium infection
Cryptosporidiosis is one of the leading causes of moderate to severe diarrhea in children in low-resource settings. The therapeutic options for cryptosporidiosis are limited to one drug, nitazoxanide, which unfortunately has poor activity in the most need
Buckner, Frederick S.,Ranade, Ranae M.,Robert Gillespie,Shibata, Sayaka,Hulverson, Matthew A.,Zhang, Zhongsheng,Huang, Wenlin,Choi, Ryan,Verlinde, Christophe L.M.J.,Hol, Wim G.J.,Ochida, Atsuko,Akao, Yuichiro,Choy, Robert K.M.,Van Voorhis, Wesley C.,Arnold, Sam L.M.,Jumani, Rajiv S.,Huston, Christopher D.,Fan, Erkang
supporting information
(2019/04/04)
OPIATE INTERMEDIATES AND METHODS OF SYNTHESIS
Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided.
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Page/Page column 24-26
(2008/06/13)
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