- Effect of substitution on novel tricyclic HIV-1 integrase inhibitors
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A series of novel tricyclic inhibitors of HIV-1 integrase enzyme was prepared. The effect of substitution at C-6 of the 9-hydroxy-6,7-dihydropyrrolo[3,4-g]quinolin-8-one compounds was studied in vitro. Inhibitors with small side chains at C-6 were general
- Fardis, Maria,Jin, Haolun,Jabri, Salman,Cai, Ruby Z.,Mish, Michael,Tsiang, Manuel,Kim, Choung U.
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p. 4031 - 4035
(2007/10/03)
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- PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS
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Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
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Page/Page column 402-403
(2010/02/15)
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- PRE-ORGANIZED TRICYCLIC INTEGRASE INHIBITOR COMPOUNDS
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Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). Al and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
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