685111-92-6

Basic information

• Product Name: MB-07133
• Synonyms: MB-07133;MB-7133;4-Amino-1-[5-O-[(2R,4S)-2-oxido-4-(4-pyridinyl)-1,3,2-dioxaphosphorinan-2-yl]-beta-D-arabinofuranosyl]-2(1H)-pyrimidinone
• CAS NO: 685111-92-6
• Molecular Formula: C17H21N4O8P
• Molecular Weight: 440.34
• Mol File: 685111-92-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: MB-07133(CAS DataBase Reference)
• NIST Chemistry Reference: MB-07133(685111-92-6)
• EPA Substance Registry System: MB-07133(685111-92-6)

Safety Data

• Hazardous Substances Data: 685111-92-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
MB-07133 is used as a therapeutic agent for the treatment of cancers driven by dysregulated SHP2 signaling. Its ability to inhibit SHP2 activity and suppress MAPK signaling makes it a promising candidate for targeting cancer cells with alterations in the SHP2 pathway.
Used in Cancer Research:
MB-07133 is used as a research tool in preclinical studies to investigate the role of SHP2 in cancer development and progression. Its potent and selective inhibition of SHP2 activity allows researchers to study the molecular mechanisms underlying the antitumor effects of MB-07133 and explore its potential as a therapeutic agent for various cancer types.
Used in Drug Development:
MB-07133 is used as a lead compound in the development of new drugs targeting the SHP2 pathway. Its promising antitumor activity and selectivity for SHP2 make it a valuable starting point for the design and optimization of novel therapeutic agents for the treatment of cancers with dysregulated SHP2 signaling.

Upstream product

• 69-74-9 cytarabine hydrochloride 
• 685111-88-0 (-)-(4S)-trans-2-(4-nitrophenoxy)-2-oxido-4-(pyridin-4-yl)-1,3,2-dioxaphosphorinane 
• 685111-87-9 (-)-(S)-1-(pyridin-4-yl)-1,3-propanediol 
• 87418-91-5 1-[2',3'-di-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl]cytosine 
• 1027138-30-2 ethyl 3-(L-2-N,N-dimethylamino-3-phenyl-propanoyloxy)-3-(pyridin-4-yl)-propanoate 
• 1026885-94-8 ethyl 3-(L-2-N,N-dimethylamino-3-phenyl-propanoyloxy)-3-(pyridin-4-yl)-propanoate 
• 329325-42-0 (+)-(R)-1-(pyridin-4-yl)-1,3-propanediol 
• 872-85-5 pyridine-4-carbaldehyde 
• 591228-11-4 3-hydroxy-3-(pyridin-4-yl)propionic acid ethyl ester 

Relevant articles and documents

Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-β-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma

Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissues. Th

Novel cytarabine monophosphate prodrugs

Compounds of Formula I, their preparation and uses are described: wherein: M and V are cis to one another and MH is cytarabine; the 5′ oxygen of said cytarabine is attached to the phosphorus; V is 4-pyridyl; and pharmaceutically acceptable prodrugs and salts thereof.