688348-25-6 Usage
Uses
Used in Environmental Toxicity Mitigation:
PDM 2 is used as a therapeutic agent for the treatment of dioxin and other aryl hydrocarbon poisonings. 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE's ability to antagonize the AhR receptor makes it a promising candidate for mitigating the harmful effects of environmental toxins that target this receptor.
Used in Research Applications:
In addition to its potential therapeutic uses, PDM 2 is utilized in research settings as a tool compound to study the role of the AhR receptor in various biological processes. Its high selectivity and potency make it a valuable asset for investigating the mechanisms of AhR-dependent signaling pathways and their implications in disease.
Used in Drug Development:
PDM 2's unique properties as an AhR antagonist also make it a candidate for further drug development. Researchers may explore its potential in the creation of new pharmaceuticals targeting the AhR pathway for the treatment of various diseases and conditions related to AhR dysregulation.
Used in Toxicology Studies:
Given the role of AhR in the response to xenobiotics, PDM 2 is used in toxicology studies to better understand the mechanisms of toxicity and to develop strategies for detoxification and protection against harmful environmental exposures.
Check Digit Verification of cas no
The CAS Registry Mumber 688348-25-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,8,3,4 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 688348-25:
(8*6)+(7*8)+(6*8)+(5*3)+(4*4)+(3*8)+(2*2)+(1*5)=216
216 % 10 = 6
So 688348-25-6 is a valid CAS Registry Number.
688348-25-6Relevant articles and documents
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor
Nakao, Syuhei,Mabuchi, Miyuki,Wang, Shenglan,Kogure, Yoko,Shimizu, Tadashi,Noguchi, Koichi,Tanaka, Akito,Dai, Yi
supporting information, p. 3167 - 3172 (2017/06/13)
A series of 31 resveratrol derivatives was designed, synthesized and evaluated for activation and inhibition of the TRPA1 channel. Most acted as activators and desensitizers of TRPA1 channels like resveratrol or allyl isothiocyanate (AITC). Compound 4z (HUHS029) exhibited higher inhibitory activity than resveratrol with an IC50 value of 16.1?μM. The activity of 4z on TRPA1 was confirmed in TRPA1-expressing HEK293 cells, as well as in rat dorsal root ganglia neurons by a whole cell patch clamp recording. Furthermore, pretreatment with 4z exhibited an analgesic effect on AITC-evoked TRPA1-related pain behavior in vivo.