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688348-25-6

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE, also known as PDM 2, is an analog of resveratrol that acts as a potent and selective aryl hydrocarbon receptor (AhR) antagonist. With a Ki of 1.2 nM, PDM 2 is highly effective in blocking the activity of AhR, a ligand-dependent intracellular transcription factor that plays a role in the response to xenobiotics such as dioxin and polyaromatics. Importantly, PDM 2 is inactive as a ligand for the estrogen receptor even at concentrations of 100 μM.

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  • 688348-25-6 Structure

  • Basic information

    1. Product Name: 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
    2. Synonyms: 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE;PDM 2;1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
    3. CAS NO:688348-25-6
    4. Molecular Formula: C14H9Cl3
    5. Molecular Weight: 283.58
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 688348-25-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 394.2±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.360±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE(688348-25-6)
    11. EPA Substance Registry System: 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE(688348-25-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 688348-25-6(Hazardous Substances Data)

688348-25-6 Usage

Uses

Used in Environmental Toxicity Mitigation:
PDM 2 is used as a therapeutic agent for the treatment of dioxin and other aryl hydrocarbon poisonings. 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE's ability to antagonize the AhR receptor makes it a promising candidate for mitigating the harmful effects of environmental toxins that target this receptor.
Used in Research Applications:
In addition to its potential therapeutic uses, PDM 2 is utilized in research settings as a tool compound to study the role of the AhR receptor in various biological processes. Its high selectivity and potency make it a valuable asset for investigating the mechanisms of AhR-dependent signaling pathways and their implications in disease.
Used in Drug Development:
PDM 2's unique properties as an AhR antagonist also make it a candidate for further drug development. Researchers may explore its potential in the creation of new pharmaceuticals targeting the AhR pathway for the treatment of various diseases and conditions related to AhR dysregulation.
Used in Toxicology Studies:
Given the role of AhR in the response to xenobiotics, PDM 2 is used in toxicology studies to better understand the mechanisms of toxicity and to develop strategies for detoxification and protection against harmful environmental exposures.

Check Digit Verification of cas no

The CAS Registry Mumber 688348-25-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,8,3,4 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 688348-25:
(8*6)+(7*8)+(6*8)+(5*3)+(4*4)+(3*8)+(2*2)+(1*5)=216
216 % 10 = 6
So 688348-25-6 is a valid CAS Registry Number.

688348-25-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-dichloro-5-[2-(4-chlorophenyl)ethenyl]benzene

1.2 Other means of identification

Product number -
Other names PDM 2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:688348-25-6 SDS

688348-25-6Downstream Products

688348-25-6Relevant articles and documents

Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor

Nakao, Syuhei,Mabuchi, Miyuki,Wang, Shenglan,Kogure, Yoko,Shimizu, Tadashi,Noguchi, Koichi,Tanaka, Akito,Dai, Yi

supporting information, p. 3167 - 3172 (2017/06/13)

A series of 31 resveratrol derivatives was designed, synthesized and evaluated for activation and inhibition of the TRPA1 channel. Most acted as activators and desensitizers of TRPA1 channels like resveratrol or allyl isothiocyanate (AITC). Compound 4z (HUHS029) exhibited higher inhibitory activity than resveratrol with an IC50 value of 16.1?μM. The activity of 4z on TRPA1 was confirmed in TRPA1-expressing HEK293 cells, as well as in rat dorsal root ganglia neurons by a whole cell patch clamp recording. Furthermore, pretreatment with 4z exhibited an analgesic effect on AITC-evoked TRPA1-related pain behavior in vivo.

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