- A β - lactam compound carboxy and hydroxy protecting group removing method (by machine translation)
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The invention discloses a β - lactam compound carboxyl and hydroxyl protecting group removal method, the method is that the carboxyl and/or hydroxyl protected β - lactam compounds in the trichloro acetic acid and carbon is ion absorbent for removing protecting group and gets the role of β - lactam compound deprotected product. The method adopts the trichloro acetic acid instead of trifluoro acetic acid, trichloro acetic acid and phenol or cresol and, anisole together, can greatly reduce the consumption of the trichloroacetic acid; in addition, trichloro acetic acid in the cephalosporin into sodium salt in the follow-up process meets the volunteer fire brigade into chloroform and carbon dioxide, is easy to remove, does not exist the problem of residual of the trichloroacetic acid, the reaction yield is high, relatively few impurities; trichloro acetic acid is inexpensive and environmentally friendly, reduce the cost beneficial to industrial production. (by machine translation)
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Paragraph 0059; 0060; 0061
(2018/04/02)
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- SALT FORMS OF CEFTOLOZANE
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This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for maki
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- CEPHEM COMPOUNDS
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The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is ; R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
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Page 36 - 37
(2010/02/06)
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